Concentraciones de DDT/DDE y riesgo de hipospadias: un estudio piloto de casos y controles

Abstract

Objective. To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias. Material and Methods. A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models. Results. Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR=0.48; 95% CI 0.15-1.60, respectively. Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9). Conclusions. Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect.