The Association between Resistin, Leptin and Adiponectin with Obesity and Type 2 Diabetes Mellitus

Abstract

Background: Obesity is an important public health concern among all age groups in the world and is a risk to develop insulin resistance and associated metabolic diseases. Fat tissue exerts important endocrine functions, which are mediated by a complex network of various soluble factors, derived from adipocytes, called adipocytokines including tumor necrosis factor a (TNF-α), Interleukin (IL) 6, leptin, adiponectin and resistin. Some adipokines play a major role in insulin resistance and cardiovascular complications associated with obesity, especially central or visceral obesity.