Superdisintegrants: Brief Review

Abstract

Oral disintegrating tablets are a new trend in novel drug delivery systems that have seen a surge in popularity in recent decades. To improve the efficacy of solid dosage forms, super disintegrants are used. This is accomplished by reducing the disintegration time, which improves the rate of drug dissolution. Disintegrants are substances or combination of substances added to a drug formulation to aid in the breaking up or disintegration of tablet or capsule content into smaller fragments that dissolve more quickly than without them. Several newer agents known as ‘Superdisintegrants’ have been developed in recent years. Superdisintegrants classified as synthetic, semi-synthetic, natural, and co-processed blends have been used to create effective mouth dissolving tablets and overcome the limitations of traditional tablet dosage form. In the solid dosage form, superdisintegrants are typically used at a low level typically (1- 10%) relative to the total weight of the dosage unit. In present studies, includes all the information about Superdisintegrants, such as their types, advantage, selection criteria, incorporation methods, ideal properties and mechanism, which are used in the formulation to provide safer, more effective drug delivery while maintaining patient conformity. Keywords: Superdisintegrants, Disintegrants, Natural, Synthetic.