Synthesis and Antifungal Activity of Azetidinone and Thiazolidinones Derivatives of 2‐Amino‐6‐(2‐naphthalenyl)thiazolo[3,2‐d]thiadiazole

Abstract

2‐Amino‐6‐(2‐naphthalenyl)thiazolo[3,2‐d]thiadiazole [1] was prepared by treatment of KCNS and Br 2 on 2‐Amino‐4‐(2‐naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a‐h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid ( i.e . mercapto acetic acid) afford 2‐azetidinones and 4‐thiazolidinones respectively. The prepared compounds have been screened on some stains of fungai.