Transition metal (II) complexes with 2- amino methyl benzimidazole derived schiff base: synthesis, characterization and biological activity

Abstract

Novel transition metal [Co(ll), Cu(ll), Ni(ll) and VO(ll)] complexes derived from Schiff bases of 2-amino methyl benzimidazole and 2-furan carbaldehyde(BNFM) have been synthesized and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligand for the complexation reaction with Co (ll),Cu(II), Ni(ll) and VO(ll) ions. The new compounds, possessing the general formula [ML2] where [M=Co (II), Cu (II), Ni(II) and VO(ll)]. The Schiff bases and their complexes have been screened for biological activity against the strains such as Escherichia coli, Staphylococcus aureus, B.Subtilis and Pseudomonas aeruginosa in order to evaluate the effect of complexation of metals with Schiff base. The metal coordinated Schiff bases have shown more antibacterial activity against bacterial species as compared to uncoordinated Schiff-bases.