Synthesis and characterization of honokiol bridged porphyrins as photosensitizers

Abstract

Four pairs of porphyrin isomers have been synthesized by reaction of 2-nitrotetraphenylporphyrin and its metallic complexes with 2-naphthol, 1,6-dibromohexane and honokiol respectively, and structurally characterized by UV-Vis, 1H NMR, H-H COSY, IR, MS, and elemental analysis. The production of singlet oxygen under radiation was determined with 1,3-diphenylisobenzofuran (DPBF) as the quencher. Their photocleavage ability to pBR322 plasmid DNA has been tested by gel electrophoresis and the interaction with CT DNA was detected by UV-Vis spectroscopy preliminarily. © 2012 Chinese Chemical Society & SIOC, CAS.