1-{[1-(Cyano-2-ethoxy-2-oxo-ethylidenaminooxy) dimethylaminomorpholinomethylene]}methane-aminium hexafluorophosphate

Abstract

(A) By combining of microwave heating and solid-phase peptide synthesis,5 Yamada and Shimizu6 prepared cyclic RGD peptides using COMU as coupling agent in good yields. In the five coupling sequences COMU was as effective as HBTU at room temperature (73% and 69% yield, respectively). Although at 50 C, the COMUpromoted coupling was faster and 84% yield instead of 39% using HBTU was obtained. © 2012 Georg Thieme Verlag Stuttgart . New York.