Animal model to study the effect of adrenal hormones on epithelial function

Abstract

An experimental animal model is described which permits an evaluation of the chronic action of aldosterone and corticosterone on epithelial function under conditons where the plasma levels of each type of major adrenal hormone can be regulated by experimental design. Experiments with this model have demonstrated the basal physiological replacement level of plasma aldosterone and the plasma level of corticosterone which does not influence the electrical properties of an aldosterone responsive epithelium.