Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog

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Abstract

Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5- tetramethyl-pyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

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Powell, J. H., Johnson, E. M., & Gannett, P. M. (2000). Improvement of a critical intermediate step in the synthesis of a nitroxide-based spin-labeled deoxythymidine analog. Molecules, 5(12), 1244–1250. https://doi.org/10.3390/51201244

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