Thermodynamic Study of Grinding-Induced Loratadine Inclusion Complex Formation Using Thermal Analysis and Curve-Fitted FTIR Determination

Abstract

Cyclodextrins (CDs) have been considerably raised interest and attention in the pharmaceutical sciences due to their specific ability to form inclusion complexes with many drugs, leading to significant enhancements of the solubility, stability and bioavailability, as well as decrease in the bitterness and tissue irritation of the drugs (Carrier et al., 2007; Challa et al., 2005; Miller et al., 2007). Thus, CDs have been extensively applied to the pharmaceutical dosage form development for various drugs. Up-to-date, over 30 CDcontaining drug products have been commercialized on the global pharmaceutical market for clinical use (Davis & Brewster, 2004; Loftsson & Brewster, 2010).