Risk of Sarcopenia, Hospitalization, and Mortality Among Malaysian Older Adults With Knee Pain: Five-Year Follow-up Study

Abstract

This study explored the longitudinal relationship between the presence of knee pain and knee osteoarthritis (OA) symptoms with risk of sarcopenia, hospitalization, and mortality. Data from Malaysian Elders Longitudinal Research (MELoR) study was utilized. The presence of knee pain and knee OA symptoms was determined at baseline between 2013 and 2015, whereas sarcopenia was determined in 2019 using SARC-F with telephone interviews. Hospitalization status was identified by asking participants “Have you been admitted to hospital since you enrolled into the MELoR study?” Death Registry data were obtained from the National Registry Department. Data from 577 individuals, mean age (SD) = 68.214 (7.095), range = 54 to 97 years, and 55.5% women at baseline, were included. Knee pain and knee OA symptoms were associated with increased risk of probable sarcopenia at follow-up, odds ratios (95% confidence interval) =2.71 [1.61, 4.58] and 2.73 [1.59, 4.71], respectively, after adjustment for confounders. Knee pain and knee OA symptoms were not associated with hospitalization and mortality. Knee pain and knee OA symptoms were associated with increased risk of probable sarcopenia at five-year follow-up in an urban older population in Kuala Lumpur. Future studies should seek to identify modifiable risk factors for the development of sarcopenia in individuals with knee OA.