Indicações em transplante de células-tronco hematopoéticas em pacientes adultos com leucemia linfoide aguda

Abstract

In acute lymphoblastic leukemia, accumulation and proliferation of immature cells infiltration characterise a heterogeneous entity, featuring a wide variety of clinical and biological aspects. In the adult LLA concentration of high-risk prognosis factors such as age, B-cell, chromosomic changes, and chiefly the presence of chromosome positive Ph. Considerations of high morbidity and mortality rates related to haematopoietic stem cell transplantation (TCTH) have generated controversy about this therapeutic modality in adult patients with LLA in first remission (1stRC). The results of conventional therapy with chemotherapy in contrast with different risk groups ofpatients with LLA, has been used for the indication of TCTH. Thus we present the algorithm indications of haematopoietic stem cell transplantation in adult patients with LLA.