Using near-infrared spectroscopy for the noninvasive identification of five pharmaceutical active substances in sealed vials

Abstract

In this study, a method combining near-infrared spectroscopy and the corresponding chemometric model was developed for the noninvasive identification of five pharmaceutical active substances in sealed vials: ceftriaxone disodium salt sterile, saquinavir mesylate, saquinavir base, nelfinavir mesylate and neuraminidase inhibitor. This method is very specific, fast and nondestructive. It is an alternative to the identification performed hitherto by infrared spectroscopy. Almost no sample preparation or cleaning operation was required apart from the filling of the actives in vials. Measurements were performed on a horizontal sample desk with a monochromator NIR spectrometer.