mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control

Abstract

Bryan D. Bryson works in the field of biological engineering with a specific interest in host-mycobacterium interactions. Bryan D. Bryson works in the field of biological engineering with a specific interest in host-mycobacterium interactions. In this mSphere of Influence article, he reflects on how “IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila ” by Price and colleagues (J. V. Price, D. Russo, D. X. Ji, R. A. Chavez, et al., mBio 10:e02629-19, 2019, https://doi.org/10.1128/mBio.02629-19 ) made an impact on him by reinforcing the complexity of intracellular pathogen control.