Glucose-6-phosphate dehydrogenase in Hansen's disease patients receiving sulfones or sulfamethoxypyridazine

Abstract

Two hundred and eighty one patients receiving sulfones (DDS, Protogen or Promin) or sulfamethoxypyridazine were glucose-6-phosphate dehydrogenase a dichlorophenol indophenol (DPIP) test for Glucose-6-phosphate dehydrogease (G6PD). The blood samples of 230 cases decolorized the dye within 80 minutes, while the residual 51 samples required 80 minutes or more. A quantitative UV test for G6PD was performed on 48 of these 51 patients. The result of the UV test showed that all of the patients had G6PD values between 120 and 240 mU per 109 red blood cells except one male patient (114.4mU). His red blood cell count and the hemoglobin index were within the normal range and Heinz body in the red blood cells was negative though he was receiving 50 mg of DDS every day.