Elevated serum levels of interferon-γ-inducible protein-10 in patients coinfected with hepatitis C virus and HIV

Abstract

Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts - HCV/HIV-coinfected patients, HCV-monoinfected patients, HIV-monoinfected patients, and healthy control subjects - were studied. Serum levels of the 10-kDa interferon-γ-inducible protein (IP-10) were higher in all 3 groups of infected patients than in control subjects (P