Polyelectrolyte Complex for Drug Delivery in Biomedical Applications: A Review

Abstract

There are so many significant developments made in drug delivery system (DDS) in which Polymer DDS has reached great developments. The main motive of this paper is to focus on DDS developing by Polyelectrolytes. Polymers have achieved much importance in DDS. Polyelectrolytes shows an exceptional category of polymer compounds containing of opposite charged polyions which are mainly cationic or anionic charges; they are hydrophilic in nature because of presence of opposite charge, can be used in various of applications in DDS. Polyelectrolytes (PE) exhibits various types of reactive groups that permits easy, adaptable modification with functional agents such as targeting molecules. Further, the oppositely charged nature exist in polyelectrolytes been used to transport macromolecules such as DNA and nanoparticles. Significance of smart polyelectrolyte is growing day by day from last several year. In the last several years, polyelectrolytes representing promising means for targeted based drug delivery and gene treatment. In the present paper, polyelectrolyte, polyelectrolyte complexes, deposition method for multilayer system, features, characterization of polyelectrolytes, and applications are reviewed.