Synthesis and antioxidant of activity of alkyl nitroderivatives of hydroxytyrosol

Abstract

A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural olive oil phenol, in order to increase the assortment of compounds with potential neuroprotective activity in Parkinson's disease. In this work, the antioxidant activity of these novel compounds has been evaluated using Ferric Reducing Antioxidant Power (FRAP), 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic1 acid) diammonium salt (ABTS), and Oxygen Radical Scavenging Capacity (ORAC) assays compared to tothat that of of nitrohydroxytyrosol (NO2HT)2 HT) and and free free HT. HT. New New compounds showed variable antioxidant activity depending on the alkyl side chain length; compounds with short chains (2-4 carbon atoms) maintained or even improved the antioxidant activity compared to NO2HT2 and/or HT, whereas those with longer side chains (6-8 carbon atoms) showed lower activity than NO2HT2 but higher than HT.