Intussusception rate among under-five- children before introduction of rotavirus vaccine in North India

Abstract

Background: Baseline data on intussusception are needed to compare the intussusception rates following introduction of rotavirus vaccine. Methods: A hospital-based bidirectional surveillance (retrospective from 2009 to 2012; and prospective from 2013 to 2015) was set up in a tertiary care hospital in Chandigarh, India, to enrol children <5 years of age admitted with intussusception as per Brighton's classification, to estimate the hospital admission rate. Incidence of intussusception among infants and children <5 years of age was also estimated. Results: A total of 277 intussusception cases (96 retrospective; 181 prospective) were reported. Majority of cases were males (69.7%) and infants (72%). Median age at diagnosis was 10 months (interquartile range 6-12 months). Nearly 62% cases were treated surgically and 33% radiologically. Incidence was estimated to be 20/100 000 infants, and 5/100 000 children <5 years of age per year, in Chandigarh. Conclusion: Intussusception surveillance system provided background hospital admission and incidence rate before rotavirus vaccine introduction in North India.