The Effect of 1,25 Dihydroxyvitamin D3 on Lymphocyte Transformation in Patients with Chronic Renal Failure

Abstract

The changes in mitogen-induced lymphocyte response occurring in nine patients undergoing chronic hemodialysis and treated with 1, 25 dihydroxyvitamin D3 (0.5 μg/day) were investigated. Prior to treatment the stimulation indices (SI) in patients with 15.4±4.2 for phytohemagglutinin (PHA) and 7.2±0.7 for conconavalin A (Con A). In the controls, stimulation indices were 44.4±13.5 and 20.2±5.3 for PHA and Con A, respectively. Following treatment, the stimulation indices increased to 36.9±6.2 for PHA (p<0.05) and 18.6±3.9 for Con A (p>0.05) indicating the beneficial effect of oral 1, 25 dihydroxyvitamin D3 treatment on lymphocyte function in patients with chronic renal failure. (Internal Medicine 34: 240-242, 1995). © 1995, The Japanese Society of Internal Medicine. All rights reserved.