Infective endocarditis in children: Profile in a 6 years experience from Dr.Mohammad Hoesin Hospital, Palembang, Indonesia

Abstract

Infective endocarditis (IE) is an inflammation or infection in the endocardium. Cardiac abnormalities represent a predisposing for the development of IE. The aim of this study is to describe the profile of IE from Mohammad Hoesin Hospital. A retrospective study was conducted from January 2011 to December 2017. Forty six children were diagnosed with IE, 67,4% of patients with aged > 5 years old. The nutritional status was 69.6% wasting and 30.4% normal. Congenital Heart Disease (CHD) was the predominant underlying heart condition (60,9%), followed by Rheumatic Heart Disease (RHD) 37% and without cardiac abnormalities (2,1%). The infective agents were identified in 50% cases, and the most frequent causative agents were Staphylococcus aureus (21.7%), followed by Staphylococcus epidermidis (10.9%), Streptococcus viridans (6.5%), Enterococcus faecalis (4.3%), Streptococcus bovis (1%), Staphylococcus haemoliticus (1%). The following complications were common: heart failure (65.2 %), pneumonia (17.4%), anemia (4.3%), pericardial effusion (4.3%) respectively.The most empirical antibiotics were ampicillin and gentamicin (82.6%) and only 1 patient underwent surgery for IE. The overall death was4.3%. The conclusion of this study is IE mostly occurs in CHD and the most organism is Staphylococcus aureus.