Assocition between LAPTM4B gene polymorphism and the risk of childhood acute lymphoblastic leukemia

Abstract

Introduction: Evidence suggests that Lysosome associated protein transmembrane 4B (LAPTM4B) contributes to the risk of numerous cancers. The present study aimed to find out the impact of LAPTM4B polymorphism on the risk of childhood acute lymphoblastic leukemia (ALL) in the southeastern Iranian population. Materials and Methods: A total of 230 subjects including 110 children diagnosed with ALL and 120 healthy children enrolled in this case-control study. Genomic DNA was extracted from the whole blood by salting out method. Genotyping of LAPTM4B polymorphism was performed by polymerase chain reaction (PCR). Results: The results showed that LAPTM4B polymorphism significantly increased the risk of ALL in codominant (OR=1.91, 95% CI =1.08-3.40, p=0.025, 1/2 vs 1/1), dominant (OR=2, 95%CI=1.14-3.54, p=0.014 1/2+2/2 vs 1/1), and allele (OR = 1.74, 95% CI = 1.10–2.75, p = 0.017, 2 vs 1) genetic models Conclusion: Conclusively, our findings showed that LAPTM4B polymorphism is the risk factor of childhood ALL in our population. Further studies with larger sample sizes and different ethnicities are needed to confirm our findings.