Recent advancements in cytotoxic T lymphocyte generation methods using carbohydrate-coated liposomes

Abstract

Both tumor-specific CD 4+ and CD 8+ T cells have been identified, and the latter is known as a major effector of adaptive antitumor immune responses. Optimal antitumor immune responses are considered to require the concomitant activation of both CD 8+ and CD 4+ T cells and the additional selective activation of CD 4+ T cells with helper, but not regulatory function. As optimal antitumor immune responses are generated by the concomitant activation of both T cell types, it is necessary for vaccine methods involving cytotoxic T-lymphocytes (CTLs) generation to possess a mechanism whereby antigen presenting cells can present administrated exogenous antigens on not only Major histocompatibility complex (MHC) class II, but also MHC class I molecules. Copyright © 2010 Yuzuru Ikehara et al.