How i treat cancer: Treatment of rheumatological side effects of immunotherapy

Abstract

Rheumatic immune-related adverse events (irAEs) have long been underestimated. However, arthralgia or myalgia are common side effects of immune checkpoint inhibitors (ICPi) reported in up to 10-20% of patients in clinical trials. Although rheumatic irAEs are rarely life-threatening, patients' quality of life can be considerably restricted due to pain, stiffness and limited mobility. Rheumatic irAEs can resemble known rheumatic and musculoskeletal diseases (RMDs), but often do not fulfil the classification criteria of classical entities and standardised evidencebased guidelines for their management are so of rheumatic irAEs and present a comprehensible diagnostic and therapeuti effects.