Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita)

Abstract

Twenty-three phenolic compounds were isolated from Dioscorea opposita by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC50 values of less than 50 μM and 3,3′,5-trihydroxy-2′-methoxybibenzyl showed the highest inhibition with an IC50 value of 8.8 μM. This study is a first to reveal the pancreatic lipase inhibitory activity by both D. opposita and its isolated compounds. © 2014 Informa UK Ltd.