Association of single and multiple-site osteoarthritis with physical and mental health-related quality of life over an 8-year period in US adults: Findings from the osteoarthritis initiative

Abstract

This study examined the association of single and multiple-site osteoarthritis (OA) at baseline with physical and mental health-related quality of life (HRQOL) over an 8-year follow-up period in the US adults compared to those at high risk of knee OA. This study is a prospective longitudinal design over 8 years of follow-up. Data from 4796 participants aged between 45 and 79 years were acquired from the osteoarthritis initiative. Based on self-reported physician-diagnosed OA and grade≥2 in either knee using Kellgren and Lawrence grade at baseline, participants were categorized into high risk of knee OA (n=1560), 1-site OA (n=1233), 2-site OA (n=1272), and≥3-site OA (n=721) groups. Physical and mental components of HRQOL were assessed over an 8-year follow-up period using the 12-item Short Form Health Survey. Two separate generalized estimating equations were used. A total of 4786 participants were included in the final model. Results from the generalized estimating equation showed that participants with 1-site OA (Beta [B]=-1.04, 95% confidence intervals [CI]: (-1.5, -.6), P