CLL therapy: progress at last!

Abstract

Teleman O, Stenflo J. Structure of the Ca(2ϩ)-free Gla domain sheds light on membrane binding of blood coagula-tion proteins. Nat Struct Biol. 1995;2:504-509. 2. Huang M, Rigby AC, Morelli X, et al. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 2003;10:751-756. 3. Regan LM, Mollica JS, Rezaie AR, Esmon CT. The inter-action between the endothelial cell protein C receptor and pro-tein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem. 1997;272:26279-26284. 4. Blostein MD, Furie BC, Rajotte I, Furie B. The Gla domain of factor IXa binds to factor VIIIa in the tenase complex. J Biol Chem. 2003;278:31297-31302. 5. Huang Q, Neuenschwander PF, Rezaie AR, Morrissey JH. Substrate recognition by tissue factor-factor VIIa: evi-dence for interaction of residues Lys165 and Lys166 of tis-sue factor with the 4-carboxyglutamate-rich domain of fac-tor X. J Biol Chem. 1996;271:21752-21757. 6. Rezende SM, Simmonds RE, Lane DA. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Blood. 2004;103:1192-1201. ● ● ● CLINICAL OBSERVATIONS Comment on Byrd et al, page 49