Chlorpromazine-methamphetamine antagonism in a non-discriminated avoidance schedule

Abstract

Rats responding under a non-discriminated avoidance schedule having a 20 sec. shock-shock and shock-response interval were dosed with 3.0 mg/kg chlorpromazine. The resultant depression of response rate was antagonized with various doses of methamphetamine thus developing a dose-effect antagonistic relationship. These data did not reflect any marked increase in drug action sensitivity over that obtained from discriminated avoidance or food reinforced techniques. © 1966, Psychonomic Press. All rights reserved.