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Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ)

Angewandte Chemie - International Edition (2017) 56(12) 3299-3303
DOI: 10.1002/anie.201612037
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Abstract

Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non-4-yne (BCN) and surface-bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART-MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.

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Sen, R., Escorihuela, J., van Delft, F., & Zuilhof, H. (2017). Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ). Angewandte Chemie - International Edition, 56(12), 3299–3303. https://doi.org/10.1002/anie.201612037

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