Prolonged delayed graft function is associated with inferior patient and kidney allograft survivals

Abstract

It is unclear if there is an association between the duration of delayed graft function (DGF) and kidney transplant (KT) outcomes. This study investigated the impact of prolonged DGF on patient and graft survivals, and renal function one year after KT. This single center retrospective analysis included all deceased donor KT performed between Jan/1998 and Dec/2008 (n = 1412). Patients were grouped in quartiles according to duration of DGF (1-5, 6-10, 11-15, and >15 days, designated as prolonged DGF). The overall incidence of DGF was 54.2%. Prolonged DGF was associated with retransplantation (OR 2.110, CI95%1.064-4.184, p = 0.033) and more than 3 HLAmismatches (OR 1.819, CI95%1.117-2.962, p = 0.016). The incidence of acute rejection was higher in patients with DGF compared with those without DGF (36.2% vs. 12.2%, p<0.001). Compared to patients without DGF, DGF(1-5), DGF(6-10), and DGF(11-15), patients with prolonged DGF showed inferior one year patient survival (95.2% vs. 95.4%vs. 95.5% vs. 93.4%vs. 88.86%, p = 0.003), graft survival (91% vs. 91.4% vs. 92% vs. 88.7%vs. 70.5%, p<0.001), death-censored graft survival (95.7%vs. 95.4% vs. 96.4%vs. 94%vs. 79.3%, p<0.001), and creatinine clearance (58.0±24.6 vs. 55.8±22.2 vs. 53.8±24.1 vs. 53.0±27.2 vs. 36.8±27.0mL/min, p<0.001), respectively. Multivariable analysis showed that prolonged DGF was an independent risk factor for graft loss (OR 3.876, CI95%2.270-6.618, p<0.001), death censored graft loss (OR 4.103, CI95%2.055-8.193, p<0.001), and death (OR 3.065, CI95%1.536-6.117, p = 0.001). Prolonged DGF, determined by retransplantation and higher HLA mismatches, was associated with inferior renal function, and patient and graft survivals at one year.