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Synthesis of 4,6-disubstituted dihydrodipyridopyrazines and assessment of their DNA binding

Revista de Chimie (2008) 59(3) 266-268
DOI: 10.37358/rc.08.3.1745
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Abstract

4,6-Disubstituted dihydrodipyridopyrazines have been synthesized and evaluated as antitumor agents. An investigation of their DNA binding capacities was performing. Compared to 4-monosubstituted dihydrodipyridopyrazines, corresponding disubstituted dihydrodipyridopyrazines showed lower affinity for DNA. Additional studies for their cytotoxic properties are underway.

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Grig-Alexa, I. C., Fînaru, A. L., Routier, S., Bailly, C., Caubere, P., & Guillaumet, G. (2008). Synthesis of 4,6-disubstituted dihydrodipyridopyrazines and assessment of their DNA binding. Revista de Chimie, 59(3), 266–268. https://doi.org/10.37358/rc.08.3.1745

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