Biomarkers and sepsis endotypes. New evidence

Abstract

Background: Sepsis is an important cause of disease and death worldwide, and it has a complex and heterogeneous disease process. It is now recognized that biological markers improve sepsis classification and may facilitate the identification of different subclasses or endotypes of patients. Objective: To analyze the current concepts in translational biology that help to understand the heterogeneity in the response of the patient with sepsis. Conclusions: There are a number of biomarkers that could be useful for constructing endo-compound types that predict uncomplicated results in sepsis. These endotypes could help identify patients who deserve early antimicrobial onset or discontinuation.