Abstract
Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
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CITATION STYLE
Kaplan, J. M., Armentano, D., Scaria, A., Woodworth, L. A., Pennington, S. E., Wadsworth, S. C., … Gregory, R. J. (1999). Novel Role for E4 Region Genes in Protection of Adenovirus Vectors from Lysis by Cytotoxic T Lymphocytes. Journal of Virology, 73(5), 4489–4492. https://doi.org/10.1128/jvi.73.5.4489-4492.1999
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