FR901451, a novel inhibitor of human leukocyte elastase from flexibacter sp. I. Producing organism, fermentation, isolation, physico-chemical and biological properties

Abstract

A novel human leukocyte elastase (HLE) inhibitor, FR901451 was discovered in the fermentation broth of a bacteria. The bacteria was identified as Flexibacter sp. No. 758. FR901451 has a molecular weight of 1269 and a molecular formula of C60H79N13O18. The mode of inhibition against HLE is competitive, with a Ki value of 9.8×10-9M. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.