Changes of Rnase Activity on Dipn Induced Experimental Pancreatic Cancer

Abstract

A high incidence of experimental pancreatic cancers was induced in Syrian golden hamsters following weekly subcutaneous injections of 500 mg/kg DIPN in order to study the enzymatic diagnosis of pancreatic cancer. In morphologic aspects the induced pancreatic cancers closely resembled ductal cell adenocarcinomas of humans. After DIPN treatment the hamsters were sacrified at 12, 16, 20, 22, 25 weeks, and RNase activities (Poly U, Poly C, Poly G, Poly A) in serum and pancreatic extract were assayed respectively. Hamsters with pancreatic cancer at 25 weeks exhibited elevated uridine base specific RNase levels. These results suggest that the changes of RNase may be a good indicator in the diagnosis of pancreatic cancer. © 1980, The Japanese Society of Gastroenterology. All rights reserved.