Predictive factors for relapse in adults with dermatomyositis

Abstract

Introduction: Dermatomyositis (DM) is a severe disease that can be chronic with relapses and severe morbidity. The objective of this study was to analyze clinical features at presentation that predict non-paraneoplastic DM relapse in adult patients. Methods: A multicenter retrospective study focused on 33 patients diagnosed with DM and treated using corticosteroids from 2000 to 2015. This study also aimed to compare patients with and without relapse based on some predictive factors such as demo-graphic characteristics and clinical symptoms. A Cox model was used to estimate hazard ratios (HRs). Results: We identified 33 patients with an average age of 41.8 ± 12 years (range 18–68 years). The sex ratio of females to males was 2:1. During the 13.5-month follow-up period, two (6%) patients died and 21 (63.6%) suffered from a relapse. In univariate analy-sis, skin ulceration in the initial presentation of disease (HR = 3.1, range 1.1 to 15.1) was significantly associated with a relapsing course. Conclusions: This study demonstrates that in the initial presentation of the disease skin ulceration is significant in allowing predic-tion of the occurrence of DM relapse.