Interactome of invadopodia scaffold protein TKS5

Abstract

TKS5 is a scaffold protein that takes part in invadopodia functioning and reactive oxygen species (ROS) production. TKS5 is a critical component of invadopodia as its absence results in the loss of cancer cells ability to form these invasive structures. TKS5 is phosphorylated by SRC kinase and consequently interacts with the membrane phosphatidylinositol phosphates launching the invadopodia formation process. At later stages TKS5 regulates the actin cytoskeleton reorganization and extracellular matrix degradation. TKS5 also regulates the production of ROS, which are the important signal regulators of different cellular functions.