Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation

31Citations
Citations of this article
38Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Inflammatory damage of mucosal surface of the eye is a hallmark of dry eye disease (DED) and, in severe cases, can lead to significant discomfort, visual impairment, and blindness. DED is a multifactorial autoimmune disorder with a largely unknown pathogenesis. Using a cross-sectional patient study and a well-characterized murine model of DED, herein we investigated the immunoregulatory function of interleukin-22 (IL-22) in the pathogenesis of DED. We found that IL-22 levels were elevated in lacrimal fluids of DED patients and inversely correlated with severity of disease. Acinar cells of the lacrimal glands (LGs), not inflammatory immune cells, are the primary source of IL-22, which suppresses inflammation in ocular surface epithelial cells upon desiccating stress. Moreover, loss of function analyses using IL-22 knockout mice demonstrated that IL-22 is essential for suppression of ocular surface infiltration of Th17 cells and inhibition of DED induction. Our novel findings elucidate immunoregulatory function of LG-derived IL-22 in inhibiting IL-17-mediated ocular surface epitheliopathy in DED thus making IL-22 a new relevant therapeutic target.

References Powered by Scopus

IL-22 increases the innate immunity of tissues

1220Citations
N/AReaders
Get full text

Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

880Citations
N/AReaders
Get full text

Therapeutic opportunities of the IL-22-IL-22R1 system

482Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Review of Biomarkers in Ocular Matrices: Challenges and Opportunities

121Citations
N/AReaders
Get full text

Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

81Citations
N/AReaders
Get full text

Proteomic analysis of human lacrimal and tear fluid in dry eye disease

70Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ji, Y. W., Mittal, S. K., Hwang, H. S., Chang, E. J., Lee, J. H., Seo, Y., … Lee, H. K. (2017). Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation. Mucosal Immunology, 10(5), 1202–1210. https://doi.org/10.1038/mi.2016.119

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 10

59%

Researcher 5

29%

Professor / Associate Prof. 2

12%

Readers' Discipline

Tooltip

Medicine and Dentistry 9

47%

Immunology and Microbiology 6

32%

Biochemistry, Genetics and Molecular Bi... 3

16%

Pharmacology, Toxicology and Pharmaceut... 1

5%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free