Sirolimus-induced lymphoedema

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Abstract

Sirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney transplant recipient with this complication in a resource-limited environment. Lymphoedema is a rare complication of sirolimus, and the mechanisms are not completely understood; however, early recognition can prevent permanent disfiguration. This case highlights the need for early recognition of adverse drug effects and further research into their pathophysiology and management.

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Motse, K. G., & Mashabane, M. J. (2016). Sirolimus-induced lymphoedema. South African Medical Journal, 106(9), 886–887. https://doi.org/10.7196/SAMJ.2016.v106i9.10636

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