Obesity and diabetes are often associated with lipotoxic conditions in multiple tissues. The insulin-producing b cells are susceptible to elevated lipid levels and the ensuing lipotoxicity. The preservation of b cell mass and function is one of the main goals of diabetes management under these metabolically stressful conditions. However, the adverse effects from the adaptive signaling pathways that b cells use to counteract lipotoxic stress have secondary negative effects in their own right. Antilipotoxic signaling cascades in b cells can contribute to their eventual failure. Such dual roles are seen for many other biological adaptive processes as well.
CITATION STYLE
Ye, R., Onodera, T., & Scherer, P. E. (2019). Lipotoxicity and B cell maintenance in obesity and type 2 diabetes. Journal of the Endocrine Society, 3(3), 617–631. https://doi.org/10.1210/js.2018-00372
Mendeley helps you to discover research relevant for your work.