Lipotoxicity and B cell maintenance in obesity and type 2 diabetes

72Citations
Citations of this article
118Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Obesity and diabetes are often associated with lipotoxic conditions in multiple tissues. The insulin-producing b cells are susceptible to elevated lipid levels and the ensuing lipotoxicity. The preservation of b cell mass and function is one of the main goals of diabetes management under these metabolically stressful conditions. However, the adverse effects from the adaptive signaling pathways that b cells use to counteract lipotoxic stress have secondary negative effects in their own right. Antilipotoxic signaling cascades in b cells can contribute to their eventual failure. Such dual roles are seen for many other biological adaptive processes as well.

Cite

CITATION STYLE

APA

Ye, R., Onodera, T., & Scherer, P. E. (2019). Lipotoxicity and B cell maintenance in obesity and type 2 diabetes. Journal of the Endocrine Society, 3(3), 617–631. https://doi.org/10.1210/js.2018-00372

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free