Contrast-to-noise ratio for liver parenchyma of the large arterial blood maximum density of Gd-EOB-DTPA and Gd-DTPA in first pass dynamic study (3D-FSPGR technique)

Abstract

From the difference of a clinical dose and the molarity of hepatic specificity contrast agent Gadoxetate Sodium (Gd-EOB-DTPA) and Meglumine Gadopentetate (Gd-DTPA), we make one's own phantom this time, we performed a study of the base about contrast-to-noise ratio (CNR) of the three dimensional-fast spoiled gradient echo (3D-FSPGR) technique and an optimum flip angle (FA) and the bandwidth (BW) for Gd-DTPA dilution 0.3 mmol/l which assumed T1 value of the liver parenchyma of Gd-DTPA dilution 6.0 mmol/l and Gd-EOB-DTPA dilution 1.5 mmol/l which assumed large arterial blood maximum density of first pass in Dynamic study. We assume CNR of FA10 in each BW criteria, CNR of Gd-DTPA dilution 6.0 mmol/l becomes the 3.63-4.38 double at the maximum in FA30 with each BW; CNR of Gd-EOB-DTPA dilution 1.5mmol/l is with 1.95-2.36 double at the maximum in FA 20-25 with each BW. When CNR compares it with a value of FA becoming biggest, with each BW, as for Gd-EOB-DTPA dilution 1.5 mmol/l, about around 40% CNR lowered for Gd-DTPA dilution 6.0 mmol/l. In Dynamic study in Gd-EOB-DTPA, we did not use an imaging condition totally same as Gd-DTPA and understood that we required the setting of the imaging condition that considered the influence of the T1 relaxation time by the difference of a clinic dose and the molarity in first pass.