Synthesis and In Vitro Evaluation of Anti-Leukemic Potency of Some Novel Azo-Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

Abstract

Synthesis of some new mono azo organic compounds, based on 1-arylazo-2-naphthol nucleus is performed by diazo-coupling strategy of β-naphthol with different 1ry aromatic amines. Interestingly, the monoazo products undergo functionalized reactions to obtain the target azo naphthol derivatives (3–14). The synthesized dyes are conjugated with gold and/ or silver nanoparticles by electrostatic interaction. Photodynamic therapeutic efficiencies of the synthesized naphthol azo dyes and their conjugates have been evaluated against promyelocytic leukemia cell lines (HL-60) in dark and light conditions. Dye-Nanometal conjugates act as photosensitizers (PSs) exhibiting an enhancement of the optical properties as well as in photodynamic therapeutic efficiencies in variable degrees depending on dye structure.