Conglutinin - An important element of natural immunity in ruminants (a review)

Abstract

Conglutinin represents a collectin appearing only in some mammals, including cattle. It plays an important role in resistance of hosts against microbes and parasites. It exhibits affinity toward saccharides present on the surface of bacteria, viruses, fungi and parasites and it mobilizes the mechanisms leading to their inactivation. It manifests also the unique ability of agglutinating complement- and antibody-coated erythrocytes. Moreover, it shows the ability to activate immune system cells, including the process of phagocytosis. In this review also the factors that determine the amount and activity of conglutinin in mammalian serum were presented, including environmental conditions and infectious agents, such as various types of bacteria and viruses. The broad scope of conglutinin is genetically controlled and, therefore, this collectin may constitute a useful and crucial factor in cattle husbandry.