Usefulness of PET–CT in the evaluation of suspected recurrent ovarian carcinoma

Abstract

Background: The purpose of the current study is to assess the PET/CT potential value in the diagnosis of ovarian cancer recurrence. Results: PET/CT scan described suspicion of ovarian cancer (OC) recurrence in 20 local pelvic lesions with 100% sensitivity, accuracy, and specificity and in 18 peritoneal lesions with sensitivity and specificity of 76.19 and 95.65 and accuracy of 89.55%. While PET/CT suspected OC recurrence in 5 pelvic, 9 para-aortic, and 10 distant lymph nodes, the sensitivity, specificity, and accuracy were (80, 98.38, and 97 %), (66.67, 94.82, and 91.04%), and (90, 98.24, and 97.01), respectively. PET/CT scan described suspicion of OC recurrence in 5 distant organ metastases; the accuracy, sensitivity, and specificity were 100%. The lesion-based accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT scan were 95.77, 85.7, 97.89, 90.5 and 97% while the corresponding patient-based values were 94.44, 96.87, 75, and 94.44% and 96.87 and 75%. Conclusion: PET–CT is a helpful modality in the assessment of OC recurrence; it can detect and localize the recurrence with high accuracy, thus can influence and modify the treatment plan, and reduces the need for 2nd look surgery.