TRANSDERMAL DRUG DELIVERY SYSTEMS: A MINI REVIEW.

Abstract

In the last two decades, the transdermal drug delivery has become a proven technology that offers vide range of advantages than conventional route. Because transdermal drug delivery offers controlled as well as predetermined rate of release of the drug into the patient, and it can easily terminate the drug action, whenever is required. First-generation transdermal delivery has delivered small, lipophilic, low dose drugs. Second-generation transdermal delivery has used ultrasound, iontophoresis and chemical enhancers in delivering the drug. Third-generation transdermal delivery has used microneedles, electroporation, thermal ablation, microdermabrasion, in delivering the drug. This review emphasizes the various modules used in delivery of drug with topical application. The main aim of transdermal drug delivery system is to deliver the drug into systemic circulation with minimal inter and intrasubject variability.