Morin attenuates interleukin-1β-induced inflammatory response in primary rat chondrocytes by suppressing the overproduction of nitric oxide and matrix metalloproteinases

Abstract

The present investigation was aimed to evaluate the antiosteoarthritic effect of morin in isolated primary rat chondrocytes in the presence of interleukin-1β. Results obtained showed that morin effectively attenuated in vitro the production of inflammatory mediators, nitric oxide and prostaglandin E2. Moreover, morin also significantly decreased the levels of matrix metalloproteinases. Furthermore, in monosodium iodoacetateinduced osteoarthritis in mice, it was found that morin at 25 and 50 mg/kg, significantly reduced the heat hyperalgesia and increased the spontaneous motility in mice on days 7, 14, and 21. Besides, morin also significantly reduced the level of proinflammatory cytokines in the serum of osteoarthritic mice. Collectively, these findings demonstrated that morin could be a potential chondroprotective that could be used in the treatment of osteoarthritis.