Two new glycosidal metabolites of endophytic fungus Penicillium sp. (NO.4) from Tapiscia sinensis

Abstract

Two new glycosides, 8-O-β-D-glucopyranosyl-6-methyl-1-carboxylate methyl ester xanthone (1) and 4'-O-β-d-galactopyranosyl djalonensone (2), together with four known compounds, 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate methyl ester (3), cassionllin (4), djalonensone (5) and alternariol (6), were isolated from the endophytic fungus Penicillium sp. (NO.4) of Tapiscia sinensis Oliv. The structures of compounds 1-6 were elucidated by the analysis of 1D and 2D NMR and HRMS. The cytotoxic activities of these compounds were evaluated against four cancer cell lines, as well as antimicrobial activities against two plant-pathogenic microbes. Compounds 1-6 showed moderate cytotoxicity against the A549 cancer cell line with IC50values ranging from 6.8 to 35.8 μg mL-1and were found to be inactive against three other cancer cell lines MCF-7, Caski and Hep G-2.