Thyroid neoplasia following irradiation for medulloblastoma. Report of two cases

Abstract

Thyroid neoplasms occurred in two patients 14 and 18 years after treatment with radiation for medulloblastoma. One patient had a papillary cancer and the other patient had multiple adenomas and a Hurthle cell adenoma. In addition, the latter case had foci of hyperplasia plus a microfollicular transformation which has not been described in association with prior thyroid irradiation. The radiation doses delivered to the thyroid through posterior cervical spinal ports (2000‐3000 roentgens) fall within the upper range of radiation dosage associated with induction of neoplastic changes within the thyroid. Copyright © 1979 American Cancer Society