Oxidative stress modulation immediately after hemodialysis

Abstract

AIM: The aim of this study was to estimate oxidative stress (OS) before and after dialysis in hemodialysis (HD) patients and correlate this stress with routine biochemical parameters. METHOD: Sera of patients (n = 21), under regular HD, were collected 5 minutes before and after an HD session. Oxidative stress was estimated using the pro-oxidant-antioxidant assay (PAB), along with routine biochemical parameters in the same sera. RESULTS: A significant increase of OS value was observed in HD patients 5 minutes after dialysis. Before HD, a significant correlation was established between the PAB values and fasting blood sugar, calcium, and C-reactive protein (CRP); and an inverse correlation between the PAB values and uric acid, serum creatinine, albumin, and albumin/globulin ratio. This correlation was not obvious after HD. PAB value, after dialysis, correlated significantly only with serum iron and inversely with alanine transaminase. CONCLUSION: This study found that the already-increased OS in HD patients is further increased immediately after dialysis. However, factors infl uencing post-dialysis OS may be different from pre-dialysis factors.