Review of Modern Eschweiler–Clarke Methylation Reaction

Abstract

This paper reviews a substantial amount of research related to the Eschweiler–Clarke methylation reaction, summarizing its mechanism, development, and applications, to present the chemical essence and history of this reaction and its importance and application in modern synthetic chemistry. In particular, this review focuses on advances regarding the Eschweiler–Clarke methylation reaction since 2000. This work will provide researchers with a comprehensive and in-depth perspective of the Eschweiler–Clarke reaction, as well as guidance and inspiration for future research and application.